HD-Mapping™ Application Summary

Whole Genome Mapping…Now in High Definition


Nabsys HD-Mapping technology enables a wide variety of key application areas providing routine, accurate, cost-effective analysis of genomic structural variant information unavailable with short read technologies. 


De Novo Map Assembly

The use of frequently nicking enzymes in HD-Mapping results in dense, accurate, and highly complete de novo assembled maps with excellent contiguity.  The maps may be used to correct and scaffold sequence contigs as well as for a range of other applications.
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SV Discovery

Highly dense de novo assembled Nabsys maps provide the necessary long-range information to allow for detection and accurate characterization of structural variants across a broad range of sizes.
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Variant Verification

The Nabsys HD-Mapping platform combined with the SV-Verify software package provides a high throughput, fully automated tool for the evaluation of structural variant calls.
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Metagenomics

Nabsys single-molecule reads derived from a complex mixture of cells provide the combination of length and information density needed to easily detect structural differences between species present in the sample as well as individual strains that are highly similar at the sequence level.
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Hybrid Assembly

Nabsys electronic single-molecule reads can be integrated with short-read sequence data in a hybrid assembly process resulting in sequence assemblies that are more accurate, contiguous, and complete.
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Strain Identification

The generation of dense, highly accurate whole genome HD maps enables accurate identification of unknown samples as well as strain-level discrimination between strains of the same species.
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High-Definition Mapping, HDM™ provides routine, accurate, cost-effective analysis of genomic structural information. The HD-Mapping platform employs fully electronic detection of tagged single DNA molecules to provide significantly higher sensitivity, accuracy, scalability, and speed of detection, in comparison to existing mapping technologies. Single-molecule reads, hundreds of kilobases in length, preserve long-range structural information while simultaneously achieving unparalleled resolution and accuracy. The data enables a variety of applications for small and large genomes, including de novo map assembly, structural variant analysis, hybrid assembly, metagenome characterization and strain identification.