Semiconductor-based tools for better genomic analysis.

Nabsys, the pioneer of electronic mapping, uses proprietary nanodetectors to analyze long DNA molecules at high velocity. Electronic detection allows Nabsys to achieve much higher resolution than can be obtained using optical mapping methods, even while the molecule is passing through the detector at over 1 million bases per second. This high velocity combined with the scalability of semiconductors allows the technology to answer questions that require extremely high-throughput, such as the characterization of tumor heterogeneity.

The platform works by adding sequence-specific tags to long DNA molecules. These molecules are then driven through the nanodetectors at high velocity using a combination of electrophoretic and hydrodynamic control. The detector reports the locations of the sequence-specific tags on the molecules. The information is then analyzed by the Nabsys suite of software tools and used for the following applications:

• Analysis of structural variation
De novo sequencing/assembly of genomes
• Validation of contigs produced from NGS data
• Characterization of sample heterogeneity