Why HD-Mapping™
Nabsys, the pioneer of electronic mapping, uses HD-Mapping™ with solid-state nanodetectors to analyze long DNA molecules at high velocity.
The HD-Mapping™ platform constructs whole-genome maps, providing routine, accurate, cost-effective analysis of genomic structural information. Nabsys electronic nanodetectors provide higher resolution and accuracy than is possible with optical detection technologies.
Electronic detection results in higher information content per single-molecule read, and the ability to construct high-density maps with long-range information, that can be used in combination with next-generation sequencing data.
How HD-Mapping Works
The HD-Mapping platform is supported by a simple and intuitive workflow. Whole genome maps are created by detecting sequence-specific tags, which are incorporated onto long DNA molecules. The tagged DNA molecules are translocated through Nabsys nanodetectors at high-velocity while electronically detecting the locations of the sequence-specific tags, enabling the creation of dense, high-definition, long-range maps, which are then analyzed by the Nabsys suite of software tools.
Fully electronic detection of tagged DNA molecules provides significantly higher sensitivity, accuracy, scalability, and speed of detection, when compared to existing mapping technologies.
As single molecules pass through the detector, the presence of the DNA backbone and the attached tags are sensed as changes in the resistance of the detector. The resulting data indicate the time between tagged sites on each DNA backbone.
The temporal events are converted to distance-based events where the distance between tags is reported in base-pairs. Signal processing of data is completed on-the-fly during data collection with minimal data storage required.
High-Performance Electronic Nanodetectors Electronic detection delivers in the following advantages over existing optical technologies
- 5X better resolution
- Instrument Cost: >10x cost reduction
- Consumables Cost: 10x cost reduction
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