Publications

Characterization of Lysinibacillus fusiformis strain S4C11: In vitro, in planta, and in silico analyses reveal a plant-beneficial microbe.

Despite sharing traits that have made the genus Bacillus agriculturally relevant, the genus Lysinibacillus remains less studied. This study characterizes Lysinibacillus fusiformis strain S4C11, isolated from the roots of an apple tree in northern Italy, using in vitro, in vivo, in planta, and in silico methods. The strain demonstrates antifungal activity against pathogens like Botrytis cinerea and promotes plant growth across various species.

Advanced genomic approaches, including High-Definition Mapping (HDM), revealed genetic pathways for biocontrol, stress resistance, and detoxification. Combined with its ability to produce volatile organic compounds and phytohormones, strain S4C11 is a versatile candidate for sustainable agriculture and bioremediation.

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Research Areas & Applications

Cancer Research
Genomic structural variations (SVs) encompass a diverse array of alterations involving large segments of the genome, such as deletions, duplications, inversions, translocations, and insertions.
Rare Disease
Structural variants are essential for diagnosing many genetic disorders and understanding their inheritance patterns.
Cell and Gene Therapy
In many patients, accurate detection and characterization of SVs are crucial for understanding disease etiology, developing targeted therapies, and designing effective gene delivery vectors.
Functional Genomics Research
DNA structural variations can impact gene expression and function. Identifying SVs is essential for deciphering the functional consequences of genetic variation.

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