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De Novo Assembly of High Density Electronic Maps Reveals Structural Diversity in Bordetella pertussis

The Nabsys HD-Mapping™ platform generates dense, high-resolution electronic maps of Bordetella pertussis strains, enabling structural analyses not achievable with traditional sequencing methods. These maps provide unparalleled accuracy and sensitivity, resolving structural differences in intervals as small as 300 base pairs. By leveraging single-molecule data, HD-Mapping differentiates highly related strains and reveals genomic rearrangements that influence virulence and vaccine resistance.

This technology’s precision supports scalable and fast analyses while maintaining high resolution. DNA samples, processed through streamlined workflows, yield comprehensive whole-genome maps for outbreak strain characterization. These findings enhance understanding of pathogenic variation and have significant implications for infectious disease research and vaccine development.

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Research Areas & Applications

Cancer Research
Genomic structural variations (SVs) encompass a diverse array of alterations involving large segments of the genome, such as deletions, duplications, inversions, translocations, and insertions.
Rare Disease
Structural variants are essential for diagnosing many genetic disorders and understanding their inheritance patterns.
Cell and Gene Therapy
In many patients, accurate detection and characterization of SVs are crucial for understanding disease etiology, developing targeted therapies, and designing effective gene delivery vectors.
Functional Genomics Research
DNA structural variations can impact gene expression and function. Identifying SVs is essential for deciphering the functional consequences of genetic variation.

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